Santa Ana is the second largest city in El Salvador, located 64 kilometers west of San Salvador, the capital city. Santa Ana has approximately 274,830 (2006) inhabitants and serves both as the capital of the department of Santa Ana and as the municipal seat for the surrounding municipality of the same name. For its administration the municipality is divided into 35 colonias (neighborhoods) and 318 small villages.
A major processing center for El Salvador's sizable coffee industry is located near Santa Ana.
Currently, the mayor of Santa Ana is Orlando Mena, from the PDC (Christian Democratic Party), a right-wing political party. Mena was reelected in local elections in March 2003.